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Research publications

UV and the Immune System

A Monoclonal Antibody to cis-Urocanic Acid Prevents the Ultraviolet-Induced Changes in Langerhans Cells and Delayed Hypersensitivity Responses in Mice, Although Not Preventing Dendritic Cell Accumulation in Lymph Nodes Draining the Site of Irradiation and Contact Hypersensitivity Responses
A El-Ghorr and M Norval

Action spectra for the trans to cis photoisomerisation of urocanic acid in vitro and in mouse skin
NK Gibbs, M Norval, NJ Traynor, M Wolf, BE Johnson, J Crosby

Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor
JP Walterscheid, DX Nghiem, N Kazimi, LK Nutt, DJ McConkey, M Norval and SE Ullrich

Characterization of a monoclonal antibody to cis-urocanic acid: detection of cis-urocanic acid in the serum of irradiated mice by immunoassay
AM Moodycliffe, M Norval, I Kimber and TJ Simpson

Differential effects of UVA1 and UVB radiation on Langerhans cell migration in mice
MS Duthie, I Kimber, RJ Dearman and M Norval

Effect of Phototherapy and Urocanic Acid Isomers on Natural Killer Cell Function
JW Gilmour, JP Vestey, S George and M Norval

Effects of phototherapy on the production of cytokines by peripheral blood mononuclear cells and on systemic antibody responses in patients with psoriasis
CD Jones, M Guckian, AA El-Ghorr, NK Gibbs and M Noval

Estimation of the effect of increasing UVB exposure on the human immune system and related resistance to infectious diseases and tumours
J Garssen, M Norval, A E1-Ghorr, NK Gibbs, CD Jones, D Cerimele, C De Simone, S Caffieri, F Dall'Acqua, FR De Gruijl, Y Sontag and H Van Loveren

Exposure to Low-Dose Ultraviolet Radiation Suppresses Delayed-Type Hypersensitivity to Herpes Simplex Virus in Mice
S Howie, M Norval and J Maingay

Expression of major histocompatibility class II antigens by Langerhans' cells in cervical intraepithelial neoplasia
RG Hughes, M Norval, SE Howie

Histamine involvement in UVB- and cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses
PH Hart, A Jaksic, G Swift, M Norval, AA El-Ghorr and JJ Finlay-Jones

IL-12 Prevents the Inhibitory Effects of cis-Urocanic Acid on Tumor Antigen Presentation by Langerhans Cells: Implications for Photocarcinogenesis S Beissert, D Rühlemann, T Mohammad, S Grabbe, A El-Ghorr, M Norval, H Morrison, RD Granstein and T Schwarz

Immune response of lambs to experimental infection with Orf virus
DL Yirrell, HW Reid, M Norval and SEM Howie

Kinetic and physical characterisation of recombinant wild-type and mutant human protoporphyrinogen oxidases
MH Maneli, AV Corrigall, HH Klump, LM Davids, RE Kirsch and PN Meissner

Nueleie Aeid Probes in Diaflnosis of Viral Diseases of Man
JK Kulski and M Norval

Quantification of urocanic acid isomers in murine skin during development and after irradiation with UVB light
M Norval, CR McIntyre, TJ Simpson, SE Howie and E Bardshiri

The effect of histamine receptor antagonists on immunosuppression induced by the cis-isomer of urocanic acid
M Norval, JW Gilmour and TJ Simpson

The effect of ultraviolet B irradiation and urocanic acid isomers on dendritic cell migration
AM Moodycliffe, M Norval, I Kimber and TJ Simpson

The effect of UV therapy on immune function in patients with psoriasis
JW Gilmour, JP Vestey and M Norval

The effects of ultraviolet light irradiation on viral infections
M Norval, A El-Ghorr, J Garssen and H Van Loveren

The mechanisms and consequences of ultraviolet-induced immunosuppression
M Norval

The role of cis-urocanic acid in UVB-induced suppression of contact hypersensitivity
S Kondo, DN Sauder, RC McKenzie, H Fujisawa, GM Shivji, A E1-Ghorr and M Norval

The role of dendritic cells in cutaneous immunity
MB Lappin, I Kimber and M Norval

The role of interleukin-4 in ultraviolet B light-induced immunosuppression
A El-Ghorr and M Norval

Transcutaneous immunisation with herpes simplex virus stimulates immunity in mice
AA El-Ghorr, RM Williams, C Heap and M Norval

Urocanic acid analogues and the suppression of the delayed type hypersensitivity response to herpes simplex virus
M Norval, TJ Simpson, E Bardshiri and SEM Howie

Urocanic acid and immunosuppression
M Norval, TJ Simpson and JA Ross

Urocanic acid isomers in human skin: analysis of site variation
G Kavanagh, J Crosby and M Noval

UV-induced changes in the immune response to microbial infections in human subjects and animal models
M Norval, J Garssen, H Van Loveren and AA El-Ghorr

Variation in lymphoproliferative responses during recrudescent orofacial herpes simplex virus infections
JP Vestey, M Norval, S Howie, J Maingay and WA Neill